Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
2019; American Association for the Advancement of Science; Volume: 11; Issue: 477 Linguagem: Inglês
10.1126/scitranslmed.aat9143
ISSN1946-6242
AutoresSusannah L. Hewitt, Ailin Bai, D. R. Shackleton Bailey, Kana Ichikawa, John Zielinski, Russell Karp, Ameya Apte, Kristen Arnold, Sima J. Zacharek, Maria S. Iliou, Khushbu Bhatt, Maija Garnaas, Faith Musenge, Ashley N. Davis, Nikhil Khatwani, Stephen Su, Graham MacLean, Samuel J. Farlow, Kristine Burke, Joshua P. Frederick,
Tópico(s)Cytokine Signaling Pathways and Interactions
ResumoLocal mRNA therapy encoding inflammatory cytokines and T cell costimulator OX40L mediates persistent anticancer immunity across tumor models.
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