The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo
2019; American Society for Microbiology; Volume: 63; Issue: 5 Linguagem: Inglês
10.1128/aac.02312-18
ISSN1098-6596
AutoresCorey S. Westfall, Ana L. Flores‐Mireles, John I. Robinson, Aaron J. L. Lynch, Scott J. Hultgren, Jeffrey P. Henderson, Petra Anne Levin,
Tópico(s)Bacterial biofilms and quorum sensing
ResumoThe antimicrobial triclosan is used in a wide range of consumer products ranging from toothpaste, cleansers, socks, and baby toys. A bacteriostatic inhibitor of fatty acid synthesis, triclosan is extremely stable and accumulates in the environment. Approximately 75% of adults in the United States have detectable levels of the compound in their urine, with a sizeable fraction of individuals (>10%) having urine concentrations equal to or greater than the minimal inhibitory concentration for
Referência(s)