Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
2019; American Association for the Advancement of Science; Volume: 11; Issue: 478 Linguagem: Inglês
10.1126/scitranslmed.aau5758
ISSN1946-6242
AutoresMatthew J. Watt, Ashlee K. Clark, Luke A. Selth, Vanessa Haynes, Natalie Lister, Richard J. Rebello, Laura H. Porter, Birunthi Niranjan, Sarah Whitby, Jennifer Lo, Cheng Huang, Ralf B. Schittenhelm, Kimberley E. Anderson, Luc Furic, Poornima R. Wijayaratne, Maria Matzaris, Magdalene K. Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio, Gail P. Risbridger, Mark Frydenberg, Daniel K. Nomura, Renea A. Taylor,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoProstate cancer depends on fatty acid uptake and remodeling of the prostate lipidome, and blocking fatty acid uptake impairs prostate tumorigenesis.
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