Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort
2019; Baishideng Publishing Group; Volume: 25; Issue: 4 Linguagem: Inglês
10.3748/wjg.v25.i4.433
ISSN2219-2840
AutoresPatricia Prieto, Rafael I. Jaén, Daniel Calle, María Gómez‐Serrano, Estefanía Núñez, María Fernández‐Velasco, Paloma Martín‐Sanz, Sergio Alonso, Jesús Vázquez, Sebastián Cerdán, Miguel A. Peinado, Lisardo Boscá,
Tópico(s)Estrogen and related hormone effects
ResumoColorectal cancer (CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2 (COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in humans.
Referência(s)