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Association between genetic obesity susceptibility and mother‐reported eating behaviour in children up to 5 years

2019; Wiley; Volume: 14; Issue: 5 Linguagem: Inglês

10.1111/ijpo.12496

2047-6310

Blandine de Lauzon‐Guillain, Yves Akoli Koudou, Jérémie Botton, Anne Forhan, Sophie Carles, Véronique Pelloux, Karine Clément, Ken K. Ong, Marie‐Aline Charles, Barbara Heude,

Regulation of Appetite and Obesity

Summary Background Many genetic polymorphisms identified by genome‐wide association studies for adult body mass index (BMI) have been suggested to regulate food intake. Objective The objective was to study the associations between a genetic obesity risk score, appetitive traits, and growth of children up to age 5 years, with a longitudinal design. Methods In 1142 children from the Etude des Déterminants pre et post natals de la santé de l'ENfant (EDEN) birth cohort, a combined obesity risk‐allele score (BMI genetic risk score [GRS]) was related to appetitive traits (energy intake up to 12 mo, a single item on appetite from 4 mo to 3 y, a validated appetite score at 5 y) using Poisson regressions with robust standard errors. The potential mediation of appetitive traits on the association between BMI‐GRS and growth was assessed by the Sobel test. Results Children with a high BMI‐GRS were more likely to have high energy intake at 1 year and high appetite at 2 and 5 years. High energy intake in infancy and high appetite from 1 year were related to higher subsequent BMI. High 2‐year appetite seemed to partially mediate the associations between BMI‐GRS and BMI from 2 to 5 years (all P ≤ 0.05). Conclusions Genetic susceptibility to childhood obesity seems to be partially explained by appetitive traits in infancy, followed by an early childhood rise in BMI.