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First time reported in vitro pharmacological activity of Heliconia rostrata (Heliconiaceae) revealed its potency in pain management over a standard analgesic drug

2018; Volume: 3; Issue: 6 Linguagem: Inglês

10.15761/bem.1000159

2399-9632

Shatil Shahriar SM, Sammy La, Rabbi F, B Bhuiyan, Md. Atiar Rahman, Nafiujjaman Md,

Transgenic Plants and Applications

Heliconia rostrata, locally known as Jhulonto Chingri in Bangladesh, is generally found in several woodlands worldwide.Even though H. rostrata is mainly farmed for beautification, this plant has diverse medicinal practices around the world.Especially, the traditional medical healers are taking advantages of using several parts of this selected plant against different ailments for thousands of decades.By inspiring from those scientific validations and as a part of identifying and discovering drugs from natural sources, evaluating the analgesic property of this reported medicinal plant was the main phenomenon of this study.The in-vitro analgesic activity of the methanolic extract of Heliconia rostrata (MEHR) was studied in Swiss albino mice (experimental animal model) by the acetic acid-induced writhing model.Oral administration of MEHR significantly lessened 23.20, 29.00, 46.38 and 58.00% of the number of writhing respectively of an oral dose of 50, 100, 200 and 400 mg/kg.On the contrary, standard analgesic drug "Aspirin" minimized the number of writhing 39.13 and 55.06% at a dosage of 200 and 400mg/kg respectively.Interestingly, 400mg and 200mg doses respectively of MEHR were more effective to reduce the mean number of abdominal constrictions in acetic acid-induced Swiss albino mice compared to the same doses of Aspirin.For the first time ever, our present study suggests that the MEHR can be considered as a potential natural source for the development of a new analgesic drug to relieve pain.Notably, we found that the MEHR is more potential and efficacious in comparison with the standard drug Aspirin for relieving pain.