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Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

2019; Royal Society of Chemistry; Volume: 48; Issue: 4 Linguagem: Inglês

10.1039/c8cs00395e

1460-4744

Xingyue Ji, Zhixiang Pan, Bingchen Yu, Ladie Kimberly De La Cruz, Yueqin Zheng, Bowen Ke, Binghe Wang,

RNA Interference and Gene Delivery

This review summarizes recent developments in using bioorthogonal chemistry in prodrug design for the delivery of traditional small molecule- and gasotransmitter-based therapeutics.