Produção Nacional
Revisado por pares
Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue
2019; Elsevier BV; Volume: 221; Linguagem: Inglês
10.1016/j.lfs.2019.02.031
ISSN1879-0631
AutoresAurora Corrêa Rodrigues, Tiago Ferreira Leal, Alexandre Costa, Franciany de Jesus Silva, Leôncio Lopes Soares, Patrı́cia C. Brum, Helen Hermana Miranda Hermsdorff, Maria do Carmo Gouveia Pelúzio, Thales Nicolau Prímola‐Gomes, Antônio José Natali,
Tópico(s)Adipose Tissue and Metabolism
ResumoInvestigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR-/- mice adipose tissue.Four- to five-month-old male wild type (WT) and β1-AR-/- mice were divided into groups: WT control (WTc) and trained (WTt); and β1-AR-/- control (β1-AR-/-c) and trained (β1-AR-/-t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. After euthanasia, white epididymal (eWAT) and inguinal (iWAT) and brown (BAT) adipose tissues were dissected and used to determine: adiposity index; adipocyte histomorphometry; cytokine concentration; and gene expression. The content of fat, protein and water of the empty carcass was determined.MCAE reduced body weight, fat mass as well as iWAT and BAT adipocyte area in β1-AR-/- animals. Aerobic exercise also diminished the concentrations of pro-inflammatory (IL-12p70, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in adipose tissue (iWAT, eWAT or BAT) of β1-AR-/- mice. However, MCAE had no effect on the expression lipolytic and thermogenic genes in β1-AR-/- mice adipose tissue.Alongside reductions in body weight, fat mass and adipocyte area eight weeks of MCAE improves the profile of inflammatory cytokines in β1-AR-/- mice adipose tissue, despite no change in Lipolytic and thermogenic gene expression.
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