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INDUÇÃO DA MIOCARDIOPATIA ISQUÊMICA EM MODELO EXPERIMENTAL MINI PORCO

2013; Sociedade de Medicina Veterinária do Estado do Rio de Janeiro; Volume: 35; Linguagem: Inglês

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Jussara Peters Scheffer, André Lacerda de Abreu Oliveira, Melissa Medeiros Markoski, Fernanda Antunes, Fabiane Azeredo Atallah, Guilherme Alexandre Soares Monteiro, Cláudio Baptista de Carvalho, Renato A. K. Kalil,

Viral Infections and Immunology Research

ABSTRACT. Scheffer J.P., Oliveira A.L.A., Markoski M., Antunes F., Atallah F.A., Monteiro G.A.S., Carvalho C.B. & Kalil R.A.K. [Induction of ischemic cardiomyopathy in experimental model mini pig]. Inducao da miocardiopatia isquemica em modelo experimental mini porco. Revista Brasileira de Medicina Veterinaria, 35(Supl. 1):45-48, 2013. Curso de Pos-Graduacao em Ciencia Animal, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego, 2000, CCTA, Sala 207-A, Parque California, Campos dos Goytacazes, RJ 28013-602, Brasil. Email: jussarapeters@yahoo.com.br The progressive increase in the prevalence and incidence of cardiovascular disease is a public health problem of increasing interest, and the acute myocardial infarction the main condition of this group of diseases to be studied. Preclinical studies are most often performed with rats or mice, and only occasionally with larger animals like dog, in recent decades was developed the mini pig, as an alternative to pre-clinical models, due to its similarity with to the human species. With this research, we seek to up reviewing studies to demonstrate that the experimental mini pig model is an ideal model for model for preclinical studies in cardiology field. We used fifteen mini pigs of Minipig Br1 lineage, who have undergone to a ischemic cardiomyopathy model, by occlusion of the major diagonal coronary paraconal the efficacy of occlusion in the formation akinetic area was evaluated by echocardiographic examination, performed after surgery, where images were compared with the test performed before occlusion. The experimental mini pig model was adequate for performing preclinical studies, and the coronary occlusion technique, satisfactory to induce ischemic cardiomyopathy.