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Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

2019; Elsevier BV; Volume: 393; Issue: 10170 Linguagem: Inglês

10.1016/s0140-6736(18)31942-1

1474-547X

Jane Armitage, Colin Baigent, Elizabeth H Barnes, D. J. Betteridge, Lisa Blackwell, Michael A. Blazing, Louise Bowman, Eugene Braunwald, Robert Byington, Christopher P. Cannon, Michael Clearfield, Helen M. Colhoun, Rory Collins, Björn Dahlöf, Kelly Davies, Barry R. Davis, James A. de Lemos, John R. Downs, Paul N. Durrington, Jonathan Emberson, Bengt Fellström, Marcus Flather, Ian Ford, Maria Grazia Franzosi, Jordan Fulcher, John A. Fuller, Curt D. Furberg, David Gordon, Shinya Goto, Antonio M. Gotto, Heather Halls, Charlie Harper, C Hawkins, William G. Herrington, G. A. Hitman, Hallvard Holdaas, Lisa Holland, Alan G. Jardine, J. Wouter Jukema, John J.P. Kastelein, Sharon Kean, Anthony Keech, Adrienne Kirby, John Kjekshus, Genell L. Knatterud, Robert H. Knopp, Wolfgang Köenig, Michael J. Koren, Vera Krane, Martin Landray, John C. LaRosa, Eva Lonn, Peter W. Macfarlane, Stephen MacMahon, Aldo P. Maggioni, Roberto Marchioli, Ian C. Marschner, Borislava Mihaylova, Lemuel A. Moyé, Sabina A. Murphy, Haruo Nakamura, Andrew Neil, Connie B. Newman, Rachel O’Connell, Chris J. Packard, Sarah Parish, Terje Pedersen, Richard Peto, Marc A. Pfeffer, Neil Poulter, David Preiss, Christina Reith, Paul M. Ridker, Michele Robertson, Frank M. Sacks, Naveed Sattar, Roland E. Schmieder, Patrick W. Serruys, Peter Sever, John Shaw, Charles L. Shear, John Simes, Peter Sleight, Enti Spata, Luigi Tavazzi, Jonathan A. Tobert, Gianni Tognoni, Andrew Tonkin, Stella Trompet, George Varigos, Christoph Wanner, Hans Wedel, Harvey D. White, John Wikstrand, Lars Wilhelmsen, Kate Wilson, Robin Young, Salim Yusuf, Faı̈ez Zannad,

Coronary Interventions and Diagnostics

Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages.