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Parallel adaptation of rabbit populations to myxoma virus

2019; American Association for the Advancement of Science; Volume: 363; Issue: 6433 Linguagem: Inglês

10.1126/science.aau7285

1095-9203

Joel M. Alves, Miguel Carneiro, Jade Yu Cheng, Ana Lemos de Matos, Masmudur M. Rahman, Liisa Loog, Paula F. Campos, Nathan Wales, Anders Eriksson, Andrea Manica, Tanja Strive, Stephen C. Graham, Sandra Afonso, Diana Bell, Laura Belmont, Jonathan P. Day, Susan Fuller, Stéphane Marchandeau, William J. Palmer, Guillaume Queney, Alison K. Surridge, Filipe Garrett Vieira, Grant McFadden, Rasmus Nielsen, M. Thomas P. Gilbert, Pedro J. Esteves, Nuno Ferrand, Francis M. Jiggins,

Microbial infections and disease research

Locating myxomatosis resistance Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have emerged in parallel in the United Kingdom, France, and Australia. Alves et al. discovered that the basis for this resistance is polygenic, with selection converging on several host immunity and proviral alleles (see the Perspective by Miller and Metcalf). Interestingly, it now seems that the virus is counterevolving immune suppressive traits. Science , this issue p. 1319 ; see also p. 1277