Produção Nacional
Revisado por pares
Subtyping of plasmid-mediated quinolone resistance among Salmonella serotypes by whole genome sequencing
2019; Elsevier BV; Volume: 94; Issue: 4 Linguagem: Inglês
10.1016/j.diagmicrobio.2019.02.015
ISSN1879-0070
AutoresFlávia Barrosa Soares, Carlos Henrique Camargo, Marcos Paulo Vieira Cunha, Elisabete Aparecida de Almeida, Amanda Maria de Jesus Bertani, Enéas Carvalho, Jacqueline Boldrin de Paiva, Sueli Aparecida Fernandes, Monique Ribeiro Tiba‐Casas,
Tópico(s)Bacteriophages and microbial interactions
ResumoMost known plasmids are identified by conferring virulence or antimicrobial resistance phenotypes and such characteristics aid in the success of the dispersion of different plasmid types between bacteria from different sources. This study aimed to perform the subtyping of the plasmid-mediated quinolone resistance, detected in Salmonella spp. A total of 34 Salmonella strains non-susceptible to ciprofloxacin were evaluated. Strains were selected based on the presence of PMQR determined by Polymerase Chain Reaction and further submitted to Next Generation Sequencing. Most of the strains presented the qnrB19 in small ColE-like plasmids and qnrB2 gene associated with IncN/ST5 plasmids also detected. Our results indicated the co-occurrence of PMQR and ESBLs in plasmids that are a lineage of epidemic plasmids circulating in Salmonella in which additional resistances were detected, highlighting the potential threat of resistance Salmonella to public health, particularly in infections in which antimicrobial therapy is needed.
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