Portal de Periódicos da CAPES

Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis

2019; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/j.jacbts.2018.10.008

2452-302X

Heather Teague, Nevin Varghese, Lam C. Tsoi, Amit K. Dey, Michael Garshick, Joanna I Silverman, Yvonne Baumer, Charlotte Harrington, Erin Stempinski, Youssef Elnabawi, Pradeep K. Dagur, Kairong Cui, Ilker Tunc, Fayaz Seifuddin, Aditya A. Joshi, Elena Stansky, Monica Purmalek, Justin Rodante, Andrew Keel, Tarek Aridi, Carmelo Carmona‐Rivera, Gregory E. Sanda, Marcus Y. Chen, Mehdi Pirooznia, J. Philip McCoy, Joel M. Gelfand, Keji Zhao, Jóhann E. Guðjónsson, Martin P. Playford, Mariana J. Kaplan, Jeffrey S. Berger, Nehal N. Mehta,

Psoriasis: Treatment and Pathogenesis

Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.