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Macromol. Biosci. 7/2010

2010; Wiley; Volume: 10; Issue: 7 Linguagem: Inglês

10.1002/mabi.201090013

1616-5195

Huaying Zhao, Patrick H. Brown, Andrea Balbo, María del Carmen Fernández‐Alonso, Natasha Polishchuck, Charu Chaudhry, Mark L. Mayer, Rodolfo Ghirlando, Peter Schuck,

Protein purification and stability

Back Cover: The image displays Svedberg's analytical centrifuge along with a recent development in analytical ultracentrifugation (AUC), a new computational model for the analysis of macromolecules in sedimentation velocity. The plot shows macromolecular concentration profiles superimposed by solvent signals, such as those arising from optically mismatched small co-solutes. The macromolecular boundaries appear obscure and twisted due to the buffer signal and are not interpretable using traditional analysis. The new model accounts simultaneously for macromolecular and small co-solvent concentration distributions. Further details can be found in the full paper by H. Zhao,* P. H. Brown, A. Balbo, M. d. C. F. Alonso, N. Polishchuck, C. Chaudhry, M. L. Mayer, R. Ghirlando, and P. Schuck on page 736. Photograph is courtesy of Curt Ekström, The Svedberg Laboratory.