Produção Nacional
Revisado por pares
Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action
2019; Elsevier BV; Volume: 112; Linguagem: Inglês
10.1016/j.biopha.2019.108643
ISSN1950-6007
AutoresDébora Cássia Vieira Gomes, Marcus Vinícius Oliveira Barros de Alencar, Antonielly Campinho dos Reis, Rosália Maria Tôrres de Lima, José Victor de Oliveira Santos, Ana Maria Oliveira Ferreira da Mata, Ana Carolina Soares Dias, Joaquim Soares da Costa, Maria das Graças Freire de Medeiros, Márcia Fernanda Correia Jardim Paz, Lina Clara Gayoso e Almendra Ibiapina Moreno, João Marcelo de Castro e Sousa, Muhammad Torequl Islam, Ana Amélia de Carvalho Melo Cavalcante,
Tópico(s)Phytochemical compounds biological activities
ResumoBiologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Also, some bioactives with anti-inflammatory activity were reported to enhance innate and cell-mediated immune responses. Finally, compounds that presented cytotoxic/antitumoral activity induces increased free radical production, collapse of the mitochondrial membrane potential and increased expression of proteins responsible for cell cycle arrest and apoptosis. Investigating the mechanisms of action of biologically active compounds will facilitate further efforts to accelerate the discovery of novel therapeutic strategies.
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