Silencing PD-1 and PD-L1: The Potential of Polypurine Reverse Hoogsteen Hairpins for the Elimination of Tumor Cells
2019; Future Medicine; Volume: 11; Issue: 5 Linguagem: Inglês
10.2217/imt-2018-0215
ISSN1750-7448
AutoresCarlos J. Ciudad, Miriam Marlene Medina-Enríquez, Alex J. Félix, Gizem Bener, Verónique Noé,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoImmunotherapyVol. 11, No. 5 CommentarySilencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cellsCarlos J Ciudad, Mariam Marlene Medina Enriquez, Alex J Félix, Gizem Bener & Véronique NoéCarlos J Ciudad Department of Biochemistry & Physiology School of Pharmacy & Food Sciences & Institute of Nanoscience & Nanotechnology IN2UB University of Barcelona 08028 Barcelona, Spain, Mariam Marlene Medina Enriquez Department of Biochemistry & Physiology School of Pharmacy & Food Sciences & Institute of Nanoscience & Nanotechnology IN2UB University of Barcelona 08028 Barcelona, Spain, Alex J Félix Department of Biochemistry & Physiology School of Pharmacy & Food Sciences & Institute of Nanoscience & Nanotechnology IN2UB University of Barcelona 08028 Barcelona, Spain, Gizem Bener Department of Biochemistry & Physiology School of Pharmacy & Food Sciences & Institute of Nanoscience & Nanotechnology IN2UB University of Barcelona 08028 Barcelona, Spain & Véronique Noé*Author for correspondence: E-mail Address: vnoe@ub.edu Department of Biochemistry & Physiology School of Pharmacy & Food Sciences & Institute of Nanoscience & Nanotechnology IN2UB University of Barcelona 08028 Barcelona, SpainPublished Online:20 Feb 2019https://doi.org/10.2217/imt-2018-0215AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: cancer cellsimmunotherapyPD-1/PD-L1PPRHssilencingReferences1 Fife BT, Pauken KE, Eagar TN et al. 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PLoS ONE 13(11), e0206818 (2018).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsCited ByTargeting MYC Regulation with Polypurine Reverse Hoogsteen Oligonucleotides26 December 2022 | International Journal of Molecular Sciences, Vol. 24, No. 1Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides14 February 2022 | International Journal of Molecular Sciences, Vol. 23, No. 4PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing16 September 2021 | International Journal of Molecular Sciences, Vol. 22, No. 18Synthesis and validation of DOPY: A new gemini dioleylbispyridinium based amphiphile for nucleic acid transfectionEuropean Journal of Pharmaceutics and Biopharmaceutics, Vol. 165Nucleic acids therapeutics using PolyPurine Reverse Hoogsteen hairpinsBiochemical Pharmacology, Vol. 189Gene Correction of Point Mutations Using PolyPurine Reverse Hoogsteen Hairpins Technology29 October 2020 | Frontiers in Genome Editing, Vol. 2Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins16 July 2020 | International Journal of Molecular Sciences, Vol. 21, No. 14Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian CellsMolecular Therapy - Nucleic Acids, Vol. 19 Vol. 11, No. 5 Follow us on social media for the latest updates Metrics Downloaded 76 times History Received 31 December 2018 Accepted 10 January 2019 Published online 20 February 2019 Published in print April 2019 Information© 2019 Future Medicine LtdKeywordscancer cellsimmunotherapyPD-1/PD-L1PPRHssilencingAuthor contributionsMMM Enriquez performed acquisition, analysis and interpretation of data for the work and drafted the manuscript. AJ Felix performed acquisition, analysis and interpretation of data for the work and drafted the manuscript. G Bener performed acquisition, analysis and interpretation of data for the work and drafted the manuscript. CJ Ciudad performed conceptualization, funding acquisition, investigation, formal analysis, supervision and writing. V Noé performed conceptualization, funding acquisition, investigation, project administration, supervision and writingFinancial & competing interests disclosureThis research was funded by the Ministerio de Economia y Competitividad (SAF2014-51825-R to VN and CC) www.mineco.gob.es. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors declared that no competing interests exist. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
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