Produção Nacional
Revisado por pares
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
2019; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês
10.1038/s41467-019-08469-7
ISSN2041-1723
AutoresMichelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve L. Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo P. Doumatey, H. Richard Johnston, Nathalie Acevedo, Maria Ilma Araújo, Pedro C. Avila, Gillian M. Belbin, Eugene R. Bleecker, Carlos D. Bustamante, Luis Caraballo, Ãlvaro A. Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Alexandrina Figueiredo, Jean G. Ford, Weiniu Gan, Pierre‐Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight‐Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizée, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah A. Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Olufunmilayo I. Olopade, Zhaohui Qin, Charles N. Rotimi, Nicolas Vince, Harold Watson, Rainford Wilks, James G. Wilson, Steven L. Salzberg, Carole Ober, Esteban G. Burchard, L. Keoki Williams, Terri H. Beaty, Margaret A. Taub, Ingo Ruczinski, Rasika A. Mathias, Kathleen C. Barnes, Ayôla Akim Adégnika, Ganiyu Arinola, Ulysse Ateba-Ngoa, Gerardo Ayestas, Hrafnhildur Bjarnadóttir, Adolfo Correa, Said Omar Leiva Erazo, Marilyn G. Foreman, Cassandra Foster, Li Gao, Jingjing Gao, Leslie C. Grammer, Mark Hansen, Tina V. Hartert, Yi‐Juan Hu, Iain R. Konigsberg, Kwang‐Youn A. Kim, Pamela Landaverde-Torres, Javier Marrugo, B. Martínez, Rosella Martinez, L Mayorga, Delmy-Aracely Mejia-Mejia, Catherine Meza, Solomon K. Musani, Shaila Musharoff, Oluwafemi Oluwole, Maria Pino‐Yanes, Hector Ramos, Allan Saenz, Maureen Samms‐Vaughan, R.P. Schleimer, Alan L. Scott, Suyash Shringarpure, Wei Song, Zachary A. Szpiech, R. A. de A. Torres, Gloria Varela, Olga Marina Vasquez, Francisco M. De La Vega, Lorraine B. Ware, Maria Yazdanbakhsh,
Tópico(s)IL-33, ST2, and ILC Pathways
ResumoAbstract Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
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