Portal de Periódicos da CAPES

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

2019; American Thoracic Society; Volume: 199; Issue: 9 Linguagem: Inglês

10.1164/rccm.201809-1650oc

1535-4970

David N. O’Dwyer, Shanna L. Ashley, Stephen J. Gurczynski, Meng Xia, Carol A. Wilke, Nicole R. Falkowski, Katy C. Norman, Kelly B. Arnold, Gary B. Huffnagle, Margaret L. Salisbury, MeiLan K. Han, Kevin R. Flaherty, Eric S. White, Fernando J. Martínez, John R. Erb‐Downward, Susan Murray, Bethany B. Moore, Robert P. Dickson,

Extracellular vesicles in disease

Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene expression, supporting a role for lung microbiota in IPF. However, the causal significance of altered lung microbiota in disease progression is undetermined.