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Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

2019; Elsevier BV; Volume: 41; Linguagem: Inglês

10.1016/j.ebiom.2019.01.060

2352-3964

Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo‐Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastassia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Chris Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo‐Mesa, Daniel Ståhl, Steven H. Sacks, María P. Hernández-Fuentes, Paramit Chowdhury,

Organ Transplantation Techniques and Outcomes

Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune signals that would precede the onset of rejection, prior to transplant damage.