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Guinea Fowl Coronavirus Diversity Has Phenotypic Consequences for Glycan and Tissue Binding

2019; American Society for Microbiology; Volume: 93; Issue: 10 Linguagem: Inglês

10.1128/jvi.00067-19

1098-5514

Kim M. Bouwman, Mattias Delpont, Frederik Broszeit, Renaud Berger, Erik A. W. S. Weerts, Marie‐Noëlle Lucas, Maxence Delverdier, Sakhia F.Z. Belkasmi, Andreas Papanikolaou, Geert‐Jan Boons, Jean‐Luc Guérin, Robert P. de Vries, Mariette Ducatez, Monique H. Verheije,

Viral gastroenteritis research and epidemiology

Avian coronaviruses cause major global problems in the poultry industry. As causative agents of huge economic losses, the detection and understanding of the molecular determinants of viral tropism are of ultimate importance. Here, we set out to study those parameters and obtained in-depth insight into the virus-host interactions of guinea fowl coronavirus (GfCoV). Our data indicate that diversity in GfCoV viral attachment proteins results in differences in degrees of affinity for glycan receptors, as well as altered avidity for intestinal tract tissues, which might have consequences for GfCoV tissue tropism and pathogenesis in guinea fowls.