Portal de Periódicos da CAPES

Individual- and community-level risk factors for ESBL Enterobacteriaceae colonization identified by universal admission screening in London

2019; Elsevier BV; Volume: 25; Issue: 10 Linguagem: Inglês

10.1016/j.cmi.2019.02.026

1469-0691

Jonathan A. Otter, Alex Natale, Rahul Batra, Olga Tosas Auguet, Eleonora Dyakova, Simon Goldenberg, Jonathan D. Edgeworth,

Salmonella and Campylobacter epidemiology

ObjectivesWe evaluated risk factors for gastrointestinal carriage of Enterobacteriaceae which produce extended-spectrum β-lactamases (ESBL-E), including individual-level variables such as antibiotic use and foreign travel, and community-level variables such as housing and deprivation.MethodsIn an observational study in 2015, all patients admitted to a London hospital group were approached to be screened for ESBL-E carriage using rectal swabs for 4 months. Patients completed a risk factor questionnaire. Those with a residential postcode in the local catchment area were linked to a database containing community-level risk factor data. Risk factors for ESBL-E carriage were determined by binary logistic regression.ResultsOf 4006 patients, 360 (9.0%) carried ESBL-E. Escherichia coli was the most common organism (77.8%), and CTX-M-type ESBLs were the most common genes (57.9% CTX-M-15 and 20.7% CTX-M-9). In multivariable analysis, risk factors for phenotypic ESBL-E among the 1633 patients with a residential postcode within the local catchment area were: travel to Asia (OR 4.4, CI 2.5–7.6) or Africa (OR 2.4, CI 1.2–4.8) in the 12 months prior to admission, two or more courses of antibiotics in the 6 months prior to admission (OR 2.0, CI 1.3–3.0), and residence in a district with a higher-than-average prevalence of overcrowded households (OR 1.5, CI 1.05–2.2). .ConclusionsBoth individual and community variables were associated with ESBL-E carriage at hospital admission. The novel observation that household overcrowding is associated with ESBL-E carriage requires confirmation, but raises the possibility that targeted interventions in the community could help prevent transmission of antibiotic-resistant Gram-negative bacteria.