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Plasminogen activator inhibitor‐1 augments damage by impairing fibrinolysis after traumatic brain injury

2019; Wiley; Volume: 85; Issue: 5 Linguagem: Inglês

10.1002/ana.25458

1531-8249

Eva‐Verena Griemert, Susanne M. Schwarzmaier, Regina Hummel, Christina Gölz, Dong Yang, Winfried Neuhaus, Małgorzata Burek, Carola Y. Förster, Ivan Petković, Raimund Trabold, Nikolaus Plesnila, Kristin Engelhard, Michael K. E. Schäfer, Serge C. Thal,

S100 Proteins and Annexins

Plasminogen activator inhibitor-1 (PAI-1) is the key endogenous inhibitor of fibrinolysis, and enhances clot formation after injury. In traumatic brain injury, dysregulation of fibrinolysis may lead to sustained microthrombosis and accelerated lesion expansion. In the present study, we hypothesized that PAI-1 mediates post-traumatic malfunction of coagulation, with inhibition or genetic depletion of PAI-1 attenuating clot formation and lesion expansion after brain trauma.