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Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

2019; Elsevier BV; Volume: 85; Issue: 11 Linguagem: Inglês

10.1016/j.biopsych.2019.01.027

1873-2402

Savani Bartholdy, Owen O’Daly, Iain C. Campbell, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean‐Luc Martinot, Marie‐Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Günter Schumann, Ulrike Schmidt, Michael A. Rapp, Éric Artiges, Sophia Schneider, Christine Bach, Tomáš Paus, Alexis Barbot, Gareth J. Barker, Arun L.W. Bokde, Nora C. Vetter, Christian Büchel, Anna Cattrell, Patrick Constant, Penny Gowland, Hans S. Crombag, Katharina Czech, Jeffrey W. Dalley, Benjamin Decideur, Tade Matthias Spranger, Tamzin L. Ripley, Nadja Heym, Herta Flor, Wolfgang H. Sommer, Birgit Fuchs, Jürgen Gallinat, Rainer Spanagel, Mehri Kaviani, Bert Heinrichs, Andreas Heinz, Naresh Subramaniam, Tianye Jia, Albrecht Ihlenfeld, James Ireland, Bernd Ittermann, Patricia Conrod, Tobias Banaschewski, Jennifer Jones, Arno Klaassen, Christophe Lalanne, Dirk Lanzerath, Claire Lawrence, Hervé Lemaître, Sylvane Desrivières, Catherine Mallik, Karl Mann, Adam C. Mar, Lourdes Martinez-Medina, Jean‐Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Yannick Schwartz, Ruediger Bruehl, Kathrin Müller, Frauke Nees, Charlotte Nymberg, Mark Lathrop, Trevor W. Robbins, Zdenka Pausová, Jani Pentillä, Francesca Biondo, Jean‐Baptiste Poline, Sarah Hohmann, Luise Poustka, Sabina Millenet, Michael N. Smolka, Juliane H. Fröhner, Maren Struve, Steven Williams, Thomas Hübner, Uli Bromberg, Semiha Aydın, John Rogers, Alexander Romanowski, Christine Schmäl, Dirk Schmidt, Stephan Ripke, Mercedes Arroyo, Herta Flor, Yolanda Peña‐Oliver, Mira Fauth‐Bühler, Xavier Mignon, Robert Whelan, Claudia Speiser, Tahmine Fadai, D.N. Stephens, Andreas Ströhle, Marie-Laure Paillère, Nicole Strache, David Theobald, Sarah Jurk, Hélène Vulser, Rubén Miranda, Juliana Yacubian, Vincent Frouin, Alexander Genauck, Caroline Parchetka, Isabel Gemmeke, Johann Kruschwitz, Katharina Weiß, Henrik Walter, Jianfeng Feng, Dimitri Papadopoulos, Irina Filippi, Alex Ing, Barbara Ruggeri, Bing Xu, Christine Macare, Congying Chu, Éanna Hanratty, Erin Burke Quinlan, Guillaume Robert, Günter Schumann, Tao Yu, Veronika Ziesch, Alicia Stedman,

Impact of Technology on Adolescents

Background Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. Methods The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172). Results At baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers. Conclusions Greater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes.