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Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

2019; Thieme Medical Publishers (Germany); Linguagem: Inglês

10.1055/s-0038-1677239

1439-7803

MM Woitok, Dennis Doleschel, ME Zoubek, Fabian Kießling, Wiltrud Lederle, FJ Cubero, Christian Trautwein,

Melanoma and MAPK Pathways

The prevalence of non-alcoholic fatty liver disease (NAFLD), including the more aggressive non-alcoholic steatohepatitis (NASH) is continuously increasing in developed countries, associated with major complications due to cirrhosis and end-stage hepatocellular carcinoma (HCC). The c-Jun N-terminal kinases (JNKs) play a crucial role in liver physiology and disease pathogenesis. In the present study, we aimed to investigate the relevance of hepatocyte-specific Jnk2 inhibition in an experimental model of chronic liver disease (CLD) -the NEMOΔhepamice.