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Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection

2019; Oxford University Press; Volume: 70; Issue: 2 Linguagem: Inglês

10.1093/cid/ciz212

1537-6591

Vikram Mehraj, Rayoun Ramendra, Stéphane Isnard, Franck P. Dupuy, Rosalie Ponte, Jun Chen, Ido P. Kema, Mohammad‐Ali Jenabian, Cecilia T. Costiniuk, Bertrand Lebouché, Réjean Thomas, Pierre Côté, Roger LeBlanc, Jean-Guy Baril, Madéleine Durand, Carl Chartrand‐Lefebvre, Cécile Tremblay, Petronela Ancuța, Nicole F. Bernard, Donald C. Sheppard, Jean‐Pierre Routy, C Milne, S Lavoie, J Friedman, M Duchastel, F Villielm, F Asselin, Michel Boissonnault, Pierre-Jean Maziade, S Lavoie, M Milne, N Z Miaki, Mathieu Thériault, Bernard Lessard, M. A. Charron, S Dufresne, Maxime Turgeon, Sylvie Vézina, Emmanuelle Huchet, J P Kerba, Marc Poliquin, S E Poulin, Pierre-Alexandre Rochette, Patrice Junod, Danièle Longpré, Robert Pilarski, E Sasseville, Louise Charest, A Hamel, A Cloutier-Blais, Samuel Massoud, F Chano, Benoît Trottier, Louise G. Labrecque, Claude Fortin, V Hal-Gagne, M.J. Romero Muñoz, Benoit Deligne, Valérie Martel‐Laferrière, Benoît Trottier, Marianne Goyer, Marty Teltscher, Alexandra de Pokomandy, Joseph Cox, E Beauchamp, Louis‐Patrick Haraoui,

Pneumocystis jirovecii pneumonia detection and treatment

Microbial translocation from the gut to systemic circulation contributes to immune activation during human immunodeficiency virus (HIV) infection and is usually assessed by measuring plasma levels of bacterial lipopolysaccharide (LPS). Fungal colonization in the gut increases during HIV-infection and people living with HIV (PLWH) have increased plasma levels of fungal polysaccharide (1→3)-β-D-Glucan (βDG). We assessed the contribution of circulating DG to systemic immune activation in PLWH.Cross-sectional and longitudinal assessments of plasma βDG levels were conducted along with markers of HIV disease progression, epithelial gut damage, bacterial translocation, proinflammatory cytokines, and βDG-specific receptor expression on monocytes and natural killer (NK) cells.Plasma βDG levels were elevated during early and chronic HIV infection and persisted despite long-term antiretroviral therapy (ART). βDG increased over 24 months without ART but remained unchanged after 24 months of treatment. βDG correlated negatively with CD4 T-cell count and positively with time to ART initiation, viral load, intestinal fatty acid-binding protein, LPS, and soluble LPS receptor soluble CD14 (sCD14). Elevated βDG correlated positively with indoleamine-2,3-dioxygenase-1 enzyme activity, regulatory T-cell frequency, activated CD38+Human Leukocyte Antigen - DR isotype (HLA-DR)+ CD4 and CD8 T cells and negatively with Dectin-1 and NKp30 expression on monocytes and NK cells, respectively.PLWH have elevated plasma βDG in correlation with markers of disease progression, gut damage, bacterial translocation, and inflammation. Early ART initiation prevents further βDG increase. This fungal antigen contributes to immune activation and represents a potential therapeutic target to prevent non-acquired immunodeficiency syndrome events.