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A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

2019; Royal Society of Chemistry; Volume: 19; Issue: 9 Linguagem: Inglês

10.1039/c9lc00027e

1473-0197

Joshua J. Whiting, Edward B. Myers, Ronald P. Manginell, Mathew Moorman, John M. Anderson, Cory S. Fix, Cody M. Washburn, Al Staton, Daniel Porter, Darin C. Graf, David R. Wheeler, Stephen W. Howell, John A. Richards, Haley Monteith, Komandoor E. Achyuthan, M. L. Roukes, Robert J Simonson,

Acoustic Wave Resonator Technologies

A small, consumable-free, low-power, ultra-high-speed comprehensive GC×GC system consisting of microfabricated columns, nanoelectromechanical system (NEMS) cantilever resonators for detection, and a valve-based stop-flow modulator is demonstrated. The separation of a highly polar 29-component mixture covering a boiling point range of 46 to 253 °C on a pair of microfabricated columns using a Staiger valve manifold in less than 7 seconds, and just over 4 seconds after the ensemble holdup time is demonstrated with a downstream FID. The analysis time of the second dimension was 160 ms, and peak widths in the second dimension range from 10-60 ms. A peak capacity of just over 300 was calculated for a separation of just over 6 s. Data from a continuous operation testing over 40 days and 20 000 runs of the GC×GC columns with the NEMS resonators using a 4-component test set is presented. The GC×GC-NEMS resonator system generated second-dimension peak widths as narrow as 8 ms with no discernable peak distortion due to under-sampling from the detector.