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New semisynthetic teicoplanin derivatives have comparable in vitro activity to that of oritavancin against clinical isolates of VRE

2019; Springer Nature; Volume: 72; Issue: 7 Linguagem: Inglês

10.1038/s41429-019-0164-1

1881-1469

Zsolt Szűcs, Eszter Ostorházi, Máté Kicsák, Lajos Nagy, Anikó Borbás, Pál Herczegh,

Biochemical and Structural Characterization

Ten analogues of a teicoplanin pseudoaglycon derivative have been synthesized with the aim of optimizing the in vitro activity of the compound against VanA type vancomycin resistant enterococci (VRE) isolated from hospitalized patients. Teicoplanin, vancomycin, and oritavancin were used as reference antibiotics for the antibacterial evaluations. One of the new derivatives exhibited far superior activity than the original compound. The in vitro MICs measured were comparable to that of oritavancin against the investigated VRE strains.