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A snapshot of antimicrobial resistance in Mexico. Results from 47 centers from 20 states during a six-month period

2019; Public Library of Science; Volume: 14; Issue: 3 Linguagem: Inglês

10.1371/journal.pone.0209865

1932-6203

Elvira Garza‐González, Rayo Morfín‐Otero, Soraya Mendoza-Olazarán, Paola Bocanegra‐Ibarias, Samantha Flores-Treviño, Eduardo Rodríguez-Noriega, Alfredo Ponce‐de‐León, Domingo Sánchez-Francia, Rafael Franco‐Cendejas, Sara Arroyo‐Escalante, Consuelo Velázquez-Acosta, Fabián Rojas‐Larios, Luis Quintanilla, Joyarit Y. Maldonado-Anicacio, Rafael Martínez Miranda, Heidy Leticia Ostos-Cantú, Abraham C. Gómez-Choel, Juan Luis Jaime-Sánchez, Laura Karina Avilés-Benítez, José Manuel Feliciano-Guzmán, Cynthia D. Peña-López, Carlos Antonio Couoh-May, Aarón Molina-Jaimes, Elda G. Vázquez -Narvaez, Joaquín Rincón-Zuno, Raúl Rivera-Garay, Aurelio Galindo-Espinoza, Andrés Martínez-Ramirez, Javier Mora, Reyna E. Corte- Rojas, Ismelda López-Ovilla, Víctor Antonio Monroy Colín, Juan Manuel Barajas-Magallón, Cecilia Teresita Morales-de-la-Peña, Efrén Aguirre-Burciaga, Mabel Coronado-Ramírez, Alina Aracely Rosales-García, María-de-J. Ayala-Tarín, Silvia Sida-Rodríguez, Bertha A. Pérez-Vega, América Navarro-Rodríguez, Gloria Edith Juárez-Velázquez, Carlos Miguel Cetina-Umaña, Juan Pablo Mena-Ramírez, Jorge Luis Canizales-Oviedo, Martha Irene Moreno-Méndez, Daniel Romero-Romero, Alejandra Arévalo-Mejía, Dulce Isabel Cobos-Canul, Gilberto Aguilar-Orozco, Jesús Silva-Sánchez, Adrián Camacho-Ortíz,

Bacterial Identification and Susceptibility Testing

We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included. Laboratories employed their usual methods to perform microbiological studies. The results were deposited into a database and analyzed with the WHONET 5.6 software.In this 6-month study, a total of 22,943 strains were included. Regarding Gram-negatives, carbapenem resistance was detected in ≤ 3% in Escherichia coli, 12.5% in Klebsiella sp. and Enterobacter sp., and up to 40% in Pseudomonas aeruginosa; in the latter, the resistance rate for piperacillin-tazobactam (TZP) was as high as 19.1%. In Acinetobacter sp., resistance rates for cefepime, ciprofloxacin, meropenem, and TZP were higher than 50%. Regarding Gram-positives, methicillin resistance in Staphylococcus aureus (MRSA) was as high as 21.4%, and vancomycin (VAN) resistance reached up to 21% in Enterococcus faecium. Acinetobacter sp. presented the highest multidrug resistance (53%) followed by Klebsiella sp. (22.6%) and E. coli (19.4%).The multidrug resistance of Acinetobacter sp., Klebsiella sp. and E. coli and the carbapenem resistance in specific groups of enterobacteria deserve special attention in Mexico. Vancomycin-resistant enterococci (VRE) and MRSA are common in our hospitals. Our results present valuable information for the implementation of measures to control drug resistance.