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Undifferentiated connective tissue disease: state of the art on clinical practice guidelines

2019; BMJ; Volume: 4; Issue: Suppl 1 Linguagem: Inglês

10.1136/rmdopen-2018-000786

2056-5933

Margarida Maria de Castro Antunes, Carlo Alberto Scirè, Rosaria Talarico, Tobias Alexander, Tadej Avčin, Chiara Belocchi, Andrea Doria, Franco Franceschini, Ilaria Galetti, Marcello Govoni, É. Hachulla, David Launay, Gemma Lepri, Carla Macieira, Marco Matucci‐Cerinic, Carlomaurizio Montecucco, Maria Francisca Moraes‐Fontes, Luc Mouthon, Sabrina Paolino, Véronique Ramoni, Chiara Tani, Sander W. Tas, Anǵela Tincani, Ronald van Vollenhoven, Margherita Zen, João Eurico Fonseca, Stefano Bombardieri, João Eurico Fonseca, M. Schneider, Vanessa Smith, Maurizio Cutolo, Marta Mosca, Lorenzo Beretta,

Systemic Lupus Erythematosus Research

The term ‘undifferentiated connective tissue disease’ (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. No specific CPG on UCTD were found, potential areas of intervention are absence of a consensus definition of UCTD, need for specific monitoring and therapeutic protocols, stratification of UCTD based on the risk of developing a defined CTD and preventive measure for the future development of a more severe condition. Patients feel uncertainty regarding the name of the disease and feel the need of a better education and understanding of these conditions and its possible changes over time.