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BIBTEX RIS

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

2019; BioMed Central; Volume: 11; Issue: 1 Linguagem: Inglês

10.1186/s13195-019-0478-z

ISSN

1758-9193

Autores

Gemma Salvadó, José Luís Molinuevo, Anna Brugulat‐Serrat, Carles Falcón, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Javier Pavı́a, Aida Niñerola‐Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillón, Karine Fauria, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert,

Tópico(s)

S100 Proteins and Annexins

Resumo

The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for multicentre research studies and clinical trials. In this study, we aimed at deriving reference Centiloid thresholds that maximize the agreement against core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in two large independent cohorts.

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