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BIBTEX RIS

Thinking outside the box: cataplexy without narcolepsy

2019; Elsevier BV; Volume: 61; Linguagem: Inglês

10.1016/j.sleep.2019.03.006

1878-5506

F.C. Lima, Elias B. Nascimento, Silmar Teixeira, Fernando Morgadinho Santos Coelho, Giuliano da Paz Oliveira,

Genetics and Neurodevelopmental Disorders

Cataplexy is a transient loss of muscle tone that can be triggered by emotions such as laughter, excitement or fear. Other causes of cataplexy include Niemann-Pick type C Disease, Angelman Syndrome, Norrie Disease, Prader-Willi Syndrome. In addition, cataplexy can be a side effect of several drugs (eg, lamotrigine, clozapine, and gamma-hydroxybutyrate). Yet, the most prevalent causes of cataplexy without narcolepsy are rare genetic diseases; which explains why cataplexy is classically linked to narcolepsy. Therefore, it is essential disconnecting cataplexy from narcolepsy especially in pediatric population and after use of a few medications. In this review, we described few conditions of cataplexy not related to narcolepsy. We performed a review of literature (MEDLINE and EMBASE database), without limited date or publication restrictions.