Biointerfaces: Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads (Adv. Mater. 12/2019)
2019; Volume: 31; Issue: 12 Linguagem: Inglês
10.1002/adma.201970086
ISSN1521-4095
AutoresSahana Gopal, Ciro Chiappini, Jelle Penders, Vincent Leonardo, Hyejeong Seong, Stephen Rothery, Yuri E. Korchev, Andrew Shevchuk, Molly M. Stevens,
Tópico(s)Graphene and Nanomaterials Applications
ResumoAdvanced MaterialsVolume 31, Issue 12 1970086 FrontispieceFree Access Biointerfaces: Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads (Adv. Mater. 12/2019) Sahana Gopal, Sahana Gopal Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UK Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorCiro Chiappini, Ciro Chiappini Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorJelle Penders, Jelle Penders Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorVincent Leonardo, Vincent Leonardo Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorHyejeong Seong, Hyejeong Seong Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorStephen Rothery, Stephen Rothery Facility for Imaging by Light Microscopy, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London, SW7 2BB UKSearch for more papers by this authorYuri Korchev, Yuri Korchev Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UKSearch for more papers by this authorAndrew Shevchuk, Andrew Shevchuk Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UKSearch for more papers by this authorMolly M. Stevens, Molly M. Stevens Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UK Department of Bioengineering, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UK Institute of Biomedical Engineering, Imperial College London, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this author Sahana Gopal, Sahana Gopal Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UK Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorCiro Chiappini, Ciro Chiappini Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorJelle Penders, Jelle Penders Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorVincent Leonardo, Vincent Leonardo Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorHyejeong Seong, Hyejeong Seong Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this authorStephen Rothery, Stephen Rothery Facility for Imaging by Light Microscopy, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London, SW7 2BB UKSearch for more papers by this authorYuri Korchev, Yuri Korchev Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UKSearch for more papers by this authorAndrew Shevchuk, Andrew Shevchuk Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UKSearch for more papers by this authorMolly M. Stevens, Molly M. Stevens Department of Materials, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UK Department of Bioengineering, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UK Institute of Biomedical Engineering, Imperial College London, Royal School of Mines, Prince Consort Road, London, SW7 2AZ UKSearch for more papers by this author First published: 19 March 2019 https://doi.org/10.1002/adma.201970086Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract In article number 1806788, Ciro Chiappini, Andrew Shevchuk, Molly M. Stevens, and co-workers show that porous silicon nanoneedles stimulate endocytic activity in mesenchymal stem cells. Endocytic pits localize around the nanoneedles leading to increased uptake of pathway-specific payloads and their endolysosomal trafficking, yet nucleic acids delivered from nanoneedles retain their biological activity, suggesting the overlap of concurrent delivery mechanisms. These findings significantly advance the current understanding of the mechanisms of intracellular delivery by nanoinjection. Citing Literature Volume31, Issue12March 22, 20191970086 RelatedInformation
Referência(s)