Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides
2019; Multidisciplinary Digital Publishing Institute; Volume: 7; Issue: 4 Linguagem: Inglês
10.3390/inorganics7040043
ISSN2304-6740
AutoresValeria Lagostina, Loredana Leone, Fabio Carniato, Giuseppe Digilio, Lorenzo Tei, Mauro Botta,
Tópico(s)Magnetism in coordination complexes
ResumoThree different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III)-chelates and chemical exchange saturation transfer (CEST) effect of the Eu(III) complexes were evaluated. The electronic properties of the substituents were shown to strongly influence the coordinated water exchange rate (kex), resulting in five times faster kex for the electron donating phenylmethoxy group compared to the electron withdrawing ethylbenzoate group.
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