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Colangitis esclerosante primaria y enfermedad inflamatoria intestinal: interrelación intestino-hígado

2019; Elsevier BV; Volume: 42; Issue: 5 Linguagem: Inglês

10.1016/j.gastrohep.2019.02.004

1578-9519

Paulina Núñez, Rodrigo Quera, Fernando Gomollón,

Gallbladder and Bile Duct Disorders

The association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern) and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.