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The implementation of RAAF in the OECD QSAR Toolbox

2019; Elsevier BV; Volume: 105; Linguagem: Inglês

10.1016/j.yrtph.2019.03.018

1096-0295

Chanita Kuseva, T.W. Schultz, Darina Yordanova, Ksenia Tankova, Stela Kutsarova, Todor Pavlov, Atanas Chapkanov, Мarin Georgiev, Andrea Gissi, Tomasz Sobański, Ovanes Mekenyan,

Agricultural safety and regulations

The Read-Across Assessment Framework (RAAF) was developed by the European Chemicals Agency (ECHA) as an internal tool providing a framework for a consistent, structured and transparent assessment of grouping of chemicals and read-across. Following a RAAF-based evaluation, also developers and users of read-across predictions outside ECHA can judge whether their read-across rationale is sufficiently robust from a regulatory perspective. The aim of this paper is to describe the implementation of RAAF functionalities in the OECD QSAR Toolbox report. These can be activated in the prediction report after performing a readacross prediction. Once the user manually selects the appropriate scenario, the RAAF assessment elements appear and are automatically aligned with the suitable category elements of the Toolbox report. Subsequently, these are evaluated as part of the category consistency assessment functionality. The implementation of the RAAF functionality is illustrated in practice with two examples.