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Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

2018; SAGE Publishing; Volume: 13; Issue: 11 Linguagem: Inglês

10.1177/1934578x1801301109

1934-578X

Suphitcha Limjiasahapong, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Narong Nuntasaen,

Phytochemical compounds biological activities

The first phytochemical investigation of the leaves and twigs of Santisukia pagetii (Bignoniaceae) using a bioassay-guided fractionation led to the isolation and identification of seventeen known compounds, including four triterpenoids, 3- O-acetylpomolic acid (1), ursolic acid (2), 3- O-acetylursolic acid (3) and siaresinolic acid (4), three iridoid glycosides, specioside (5), verminoside (6) and ambiguuside (7), three flavonoid glycosides, luteolin-7- O-neohesperidoside (8), apigenin-7- O-neohesperidoside (9) and isoquercitrin (10), two phenolic compounds, p-coumaric acid (11) and caffeic acid (12), one monoterpenoid, ( 6S)-menthiafolic acid (13), together with α-D-glucose (14), β-D-maltose (15), β-sitosterol 3- O-β-D-glucopyranoside (16), a mixture of β-sitosterol (17A) and stigmasterol (17B). Compounds 1–13 were isolated from Santisukia genus for the first time. In addition, compounds 1–7, 9 and 10 were found to be active against HIV-1 in anti-syncytium assay, while only compounds 1 and 3 were found to be active (84.4% and 87.2% inhibition at 200 μg/mL, with IC 50 values of 290.96 and 210.34 μM, respectively) against HIV-1 reverse transcriptase. Moreover, anti-HIV-1 activities of compounds 1, 3–8, and 13 were reported for the first time.