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BIBTEX RIS

New flavonoid and stilbene derivatives from the fruits of Macaranga balansae

2019; Taylor & Francis; Volume: 34; Issue: 19 Linguagem: Inglês

10.1080/14786419.2019.1587425

ISSN

1478-6427

Autores

Huong Doan Thi, Thang Pham Toan, Tran Huu Giap, Thanh Nguyen Le, Vũ Thị Kim Oanh, Nguyễn Thị Minh Hằng, Huong Tran Thi Thu, Van Minh Chau, Marc Litaudon, Van Cuong Pham,

Tópico(s)

Biological and pharmacological studies of plants

Resumo

Two new prenylated flavonoids, 4´-methyl-8-prenyltaxifolin (1) and 6,8-diprenyl-4´-methyl-naringenin (2) and a new geranylated stilbene, 4′-deprenyl-4-methoxymappain (3) together with eight known flavonoids (4–11) were isolated from the fruits of Macaranga balansae Gagnep. Their chemical structures were determined by means of spectroscopic methods including 1D, 2D NMR, and MS data. Compound 2 showed the highest cytotoxic activity against PanC1, A549, KB and LU-1 cell lines with IC50 values range from 7.89 to 22.81 µM.

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