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Oxidized Cholesterol: Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses (Adv. Mater. 14/2019)

2019; Volume: 31; Issue: 14 Linguagem: Inglês

10.1002/adma.201970098

1521-4095

Kalina Paunovska, Alejandro J. Da Silva Sanchez, Cory D. Sago, Zubao Gan, Melissa P. Lokugamage, Fatima Z. Islam, Sujay Kalathoor, Brandon R. Krupczak, James E. Dahlman,

RNA Interference and Gene Delivery

Advanced MaterialsVolume 31, Issue 14 1970098 Inside Front CoverFree Access Oxidized Cholesterol: Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses (Adv. Mater. 14/2019) Kalina Paunovska, Kalina Paunovska Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorAlejandro J. Da Silva Sanchez, Alejandro J. Da Silva Sanchez Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorCory D. Sago, Cory D. Sago Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorZubao Gan, Zubao Gan Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorMelissa P. Lokugamage, Melissa P. Lokugamage Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorFatima Z. Islam, Fatima Z. Islam Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorSujay Kalathoor, Sujay Kalathoor Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorBrandon R. Krupczak, Brandon R. Krupczak Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorJames E. Dahlman, James E. Dahlman Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this author Kalina Paunovska, Kalina Paunovska Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorAlejandro J. Da Silva Sanchez, Alejandro J. Da Silva Sanchez Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorCory D. Sago, Cory D. Sago Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorZubao Gan, Zubao Gan Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorMelissa P. Lokugamage, Melissa P. Lokugamage Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorFatima Z. Islam, Fatima Z. Islam Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorSujay Kalathoor, Sujay Kalathoor Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorBrandon R. Krupczak, Brandon R. Krupczak Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this authorJames E. Dahlman, James E. Dahlman Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, GA, 30332 USASearch for more papers by this author First published: 02 April 2019 https://doi.org/10.1002/adma.201970098Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Using mRNA to produce therapeutic proteins is a promising approach to treat genetic diseases. However, systemically delivering mRNA to cell types besides hepatocytes remains challenging. In article number 1807748, James E. Dahlman and co-workers report that a lipid nanoparticle formulated with oxidized cholesterol (instead of unmodified cholesterol) delivers Cre mRNA to hepatic endothelial cells and Kupffer cells at 0.05 mg kg−1 three-to-four times more potently than to hepatocytes. Citing Literature Volume31, Issue14April 5, 20191970098 RelatedInformation