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Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

2019; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 4 Linguagem: Inglês

10.3390/nu11040761

2072-6643

Christopher Papandreou, Nancy Babió, Andrés Díaz‐López, Miguel Ángel Martínez‐González, Nerea Becerra‐Tomás, Dolores Corella, Helmut Schröder, Dora Romaguera, Jesús Vioqué, Ángel M. Alonso‐Gómez, Julia Wärnberǵ, J. Alfredo Martínéz, Lluís Serra‐Majem, Ramón Estruch, Araceli Muñoz‐Garach, José Lapetra, Xavier Pintó, Josep A. Tur, Antoni Sureda, Aurora Bueno‐Cavanillas, Miguel Delgado‐Rodríguez, Pilar Matía‐Martín, Lidia Daimiel, Vicente Martín, Josép Vidal, Clotilde Vázquez, Emilio Ros, Miguel Ruiz‐Canela, Mònica Bulló, José V. Sorlí, Mireia Quifer, Antoni Colom, Alejandro Oncina‐Canovas, Lucas Tojal‐Sierra, Francisco Javier Barón-López, Napoleón Pérez‐Farinós, Itziar Abete, Almudena Sánchez‐Villegas, Rosa Casas, José Carlos Fernández‐García, José Manuel Santos‐Lozano, Emili Corbella, María del Mar Bibiloni, Javier Díez‐Espino, Eva M. Asensio, Laura Torras, Marga Morey, Laura Compañ‐Gabucio, Itziar Salaverria‐Lete, Juan Carlos Cenoz‐Osinaga, Olga Castañer, Jordi Salas‐Salvadó,

Exercise and Physiological Responses

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.