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RS153109 AS POSSIBLE INDICATOR OF EFFECTIVENESS OF VITAMIN D SUPPLEMENTS FOR SUPPRESSING COPD SYMPTOMS

2019; Elsevier BV; Volume: 155; Issue: 4 Linguagem: Inglês

10.1016/j.chest.2019.02.211

1931-3543

Mariam Shahid, Umbar Tayyab, Samra Kousar, Muhammad Usman Ghani, Muhammad Farooq Sabar, Tayyib Husnain,

Vitamin D Research Studies

PURPOSE: The aim of this study was to look for association of Chronic Obstructive Pulmonary Disease (COPD) with a regulatory region Single Nucleotide Polymorphism variant rs153109, located in IL27 gene on chromosome 16, in Punjabi population of Pakistan. METHODS: A total of 159 subjects were enrolled in which 82 were healthy controls and 77 were physician diagnosed COPD patients. Genotypes for rs153109, residing on 16p13, were checked to study their association with COPD with the help of SNP Typing via capillary electrophoresis. PLINK v1.9 software was used to check SNP-COPD association by applying basic allelic and genotypic models (Table 1). HaploReg was used to look for regulatory motifs altered by risk allele. RESULTS: 'T' allele for rs153109 was found to be significantly associated with COPD under Allelic and Genotypic models in studied population (Table1). HaploReg analyses showed that 'C' allele for rs153109 is known to be associated with alteration in Vitamin D Receptor (VDR) motif whereas COPD associated 'T' allele at rs153109 site is known to be associated with normal functioning of VDR. CONCLUSIONS: 'T' allele for rs153109 is hereby reported to be significantly associated with COPD symptoms in studied population of Pakistan and it is associated with normal functioning of Vitamin D Receptor in COPD patients. CLINICAL IMPLICATIONS: COPD patients that are 'T' allele carrier for rs153109 might response well to Vitamin D therapy leading to the better management of disease symptoms.