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The molecular machinery of regulated cell death

2019; Springer Nature; Volume: 29; Issue: 5 Linguagem: Inglês

10.1038/s41422-019-0164-5

1748-7838

Daolin Tang, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, Guido Kroemer,

Cell death mechanisms and regulation

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.