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Photo-Biocatalysis: Biotransformations in the Presence of Light

2019; American Chemical Society; Volume: 9; Issue: 5 Linguagem: Inglês

10.1021/acscatal.9b00656

2155-5435

Luca Schmermund, Valentina Jurkaš, Fatma Feyza Özgen, Giovanni Davide Barone, Hanna C. Büchsenschütz, Christoph K. Winkler, Sandy Schmidt, Robert Kourist, Wolfgang Kroutil,

Photoreceptor and optogenetics research

Light has received increased attention for various chemical reactions but also in combination with biocatalytic reactions. Because currently only a few enzymatic reactions are known, which per se require light, most transformations involving light and a biocatalyst exploit light either for providing the cosubstrate or cofactor in an appropriate redox state for the biotransformation. In selected cases, a promiscuous activity of known enzymes in the presence of light could be induced. In other approaches, light-induced chemical reactions have been combined with a biocatalytic step, or light-induced biocatalytic reactions were combined with chemical reactions in a linear cascade. Finally, enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction. This Review gives an overview of the various approaches for using light in biocatalysis.