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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

2019; Cell Press; Volume: 101; Issue: 2 Linguagem: Inglês

10.1016/j.neuron.2018.12.031

1097-4199

Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, Alyssa N. Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean Miller, Simon Dujardin, Ana C. Amaral, Jonathan C. Grima, Rachel E. Bennett, Katharina Tepper, Michael DeTure, Charles Vanderburg, Bianca T. Corjuc, Sarah L. DeVos, Jose A. Gonzalez, Jeannie Chew, Svetlana Vidensky, Fred H. Gage, Jérôme Mertens, Juan C. Troncoso, Eckhard Mandelkow�, Xavier Salvatella, Roderick Y. H. Lim, Leonard Petrucelli, Susanne Wegmann, Jeffrey D. Rothstein, Bradley T. Hyman,

Alzheimer's disease research and treatments

(Neuron 99, 925–940.e1–e7; September 5, 2018) In the original publication of this paper, Dr. Charles R. Vanderburg’s last name was inadvertently spelled with an “h” (Vanderburgh). This has since been corrected online. The authors apologize for the error. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s DiseaseEftekharzadeh et al.NeuronSeptember 05, 2018In BriefNuclear pore complexes control trafficking of proteins and RNA in and out of the nucleus. These studies now provide evidence that AD-related tau disrupts nuclear pore function in Alzheimer’s disease and that nuclear pore proteins cause tau to aggregate. Full-Text PDF Open Archive