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Successful Whole Genome Sequencing-guided Treatment of Mycoplasma hominis Ventriculitis in a Preterm Infant

2019; Lippincott Williams & Wilkins; Volume: 38; Issue: 7 Linguagem: Inglês

10.1097/inf.0000000000002306

1532-0987

Felicia A. Scaggs Huang, Joel E. Mortensen, Jesse Skoch, Heidi Andersen, Mary Allen Staat, Joshua K. Schaffzin, David Haslam,

Herpesvirus Infections and Treatments

We report a case of Mycoplasma hominis ventriculitis in a preterm neonate that was successfully identified with 16S ribosomal RNA sequencing and whole genome sequencing after failure to detect the pathogen with conventional diagnostic methods. The infant required doxycycline with subsequent clearance of the infection and no evidence of drug toxicity.