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Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

2019; Royal Society of Chemistry; Volume: 4; Issue: 9 Linguagem: Inglês

10.1039/c9re00087a

2058-9883

Peter Sagmeister, Jason D. Williams, Christopher A. Hone, C. Oliver Kappe,

Chemical Synthesis and Analysis

The coupling of a modular microreactor platform, real-time inline analysis by IR and NMR, and online UPLC, leads to efficient optimization of a multistep organolithium transformation to a given product without the need for human intervention.