A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum( ii ) complex
2019; Royal Society of Chemistry; Volume: 48; Issue: 22 Linguagem: Inglês
10.1039/c9dt01614g
ISSN1477-9234
AutoresAlfonso Annunziata, Maria Elena Cucciolito, Roberto Esposito, Paola Imbimbo, Ganna Petruk, Giarita Ferraro, Valerio Pinto, Angela Tuzi, Daria Maria Monti, Antonello Merlino, Francesco Ruffo,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoNew five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.
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