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BIBTEX RIS

Toxicological and pharmacologic effects of farnesol (C15H26O): A descriptive systematic review

2019; Elsevier BV; Volume: 129; Linguagem: Inglês

10.1016/j.fct.2019.04.037

1873-6351

Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Diógenes de Queiroz Dias, Alex de Souza Borges, Isaac Moura Araújo, Glacithane Lins da Cunha, Paulo Felipe Ribeiro Bandeira, Roseli Barbosa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, José Maria Barbosa‐Filho, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf,

Coenzyme Q10 studies and effects

The objective of the present study was to perform a systematic review (SR) composed of preclinical and clinical studies which investigated the toxicological and pharmacologic effects of farnesol [Molecular formula: C15H26O; IUPAC: (3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol]. This SR was performed according to PRISMA guidelines. Literature research was performed using PubMed, MEDLINE, Scopus and Web of Science databases using the descriptor combinations: "farnesol and pharmacological effect" and "farnesol and toxicology". The inclusion criteria used were original articles from preclinical and clinical studies investigating the pharmacological and toxicological effects of farnesol, published between January 1960 and December 2017 which were written in English, Portuguese and Spanish. Primary research identified 414 articles, from which 76 articles were selected for final analysis following the inclusion criteria. After grouping, 51.32 and 22.37% of the articles investigated the antimicrobial and antitumor effect, respectively. Methodological biases have been observed both in pre-clinical studies with non-human animals and in clinical trials, mainly in group allocation and blinding. This SR is the first study developed to compile the studies concerning the pharmacological and toxicological effects of farnesol. This study concludes that farnesol possesses different pharmacological and toxicological features, which permit its use as an active or a coadjuvant drug.