Produção Nacional
Revisado por pares
Preventing adolescent stress-induced cognitive and microbiome changes by diet
2019; National Academy of Sciences; Volume: 116; Issue: 19 Linguagem: Inglês
10.1073/pnas.1820832116
ISSN1091-6490
AutoresGustavo Provensi, Scheila Daiane Schmidt, Marcus Boehme, Thomaz F. S. Bastiaanssen, Barbara Rani, Alessia Costa, Kizkitza Busca, Fiona Fouhy, Conall Strain, Catherine Stanton, Patrizio Blandina, Iván Izquierdo, John F. Cryan, Maria Beatrice Passani,
Tópico(s)Gut microbiota and health
ResumoSignificance A healthy nutritional status is essential for proper brain development and for the maintenance of optimal cognitive function during adulthood and aging. The effects of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and vitamin supplementation or deficiency on neurodevelopment have been extensively studied in healthy infants and postweaning laboratory animals, but little is known about the influence of these micronutrients on the cognitive and neurochemical consequences of chronic stress during adolescence. We provide evidence that a diet supplemented with ω-3 PUFAs and vitamin A prevents deleterious cognitive impairment and shift of microbiota composition induced by social instability stress during adolescence, and that amelioration is maintained through adulthood, suggesting that a healthy diet may have long-lasting beneficial effects and help fight off neurodegenerative diseases.
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