Population Pharmacokinetics of Anidulafungin in Critically Ill Patients
2019; American Society for Microbiology; Volume: 63; Issue: 7 Linguagem: Inglês
10.1128/aac.00378-19
ISSN1098-6596
AutoresSònia Luque, William Hope, Nuria E. Campillo, Rosana Muñoz-Bermúdez, Luisa Sorlí, Jaime Barceló‐Vidal, E González-Colominas, Francisco Álvarez-Lerma, Joan Ramón Masclans, M. Montero, Juan Pablo Horcajada, Santiago Grau,
Tópico(s)Fungal Biology and Applications
ResumoA two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of Candida albicans and Candida glabrata infections.
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