Synthetic Strategies and Cascade Reactions of 2‐Cyanobenzophenones for the Access to Diverse 3,3‐Disubstituted Isoindolinones and 3‐Aryl‐3‐Hydroxyisoindolinones
2019; Wiley; Volume: 4; Issue: 17 Linguagem: Inglês
10.1002/slct.201901045
ISSN2365-6549
AutoresAntonia Di Mola, Antonio Macchia, Consiglia Tedesco, Giovanni Pierri, Laura Palombi, Rosanna Filosa, António Massa,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAbstract Herein we report new methodologies for the synthesis of the challenging ketones 2‐cyanobenzophenones, based on Suzuki‐Miyaura type cross‐coupling reactions and very mild oxidation of 2‐benzylbenzonitriles. The investigation of the reactivity of the obtained ketones highlighted a very good electrophilicity in the presence of mild carbon‐ and hetero‐nucleophiles, allowing the synthesis of 3,3‐disubstituted isoindolin‐1‐ones. All the developed methodologies are highly efficient and tolerate combinations of functional groups present on both the aromatic rings.
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